Resources

Crystallography resources:

Textbooks :

• Crystallography made Crystal Clear

Articles :

• The Anatomy of Protein Structure

• A general protocol for the crystallization of membrane proteins for X-ray structural investigation

• Introduction to protein crystallization

• Introduction to protein crystallization (2004)

• Data Processing

• Practical macromolecular cryocrystallography

• Protein Crystalization (1996)

Cryo-EM:

Textbooks:

• Single-particle Cryo-EM of Biological Macromolecules

Articles:

• Current limitations to high-resolution structure determination by single-particle cryoEM

• High-resolution cryo-EM using beam-image shift at 200 keV

• Factors that Influence the Formation and Stability of Thin, Cryo-EM Specimens

• Cryo-EM grid optimization for membrane proteins

• Understanding the invisible hands of sample preparation for cryo-EM

High-throughput Screening:

Articles:

• Improved Statistical Methods for Hit Selection in High-Throughput Screening

• Assay Validation in High Throughput Screening – from Concept to Application

• Z-factors

Kinetics:

Textbooks:

• Enzyme Kinetics Catalysis and Control: A Reference of Theory and Best Practice Methods

• Comprehensive Enzyme Kinetics

• Kinetics and Mechanism

• Enzyme Kinetics: Principles and Methods

• Enzyme Kinetics - A Modern Approach

Articles:

• A Comprehensive Guide for Assessing Covalent Inhibition in Enzymatic Assays

Protein Expression and Purification:

Textbooks:

• Structural Proteomics

• Cytivia- Ion Exchange

Articles:

• Practical protocols for production of very high yields of recombinant proteins

• Recombinant protein expression in Escherichia coli

• Membrane protein purification

• E.coli Expression systems

• Overview of Protein Expression in E. coli

Small Molecule-Protein Interactions:

Articles:

• Free-energy calculations in structure-based drug design

• Hydrogen Bonding in Globular Proteins

• Hydrogen-Bond Donors in Drug Design

Manuscript Writing:

Articles:

• How to write your first paper

• Whitesides: how to write a paper

• Writing an Abstract