Publications
For an up to date list of publications see Dr. Armstrong’s Google Scholar page
2023
27. Borlandelli V., Armstrong Z., Nin‐Hill A., Codée J.D.C., Raich L., Artola M., Rovira C., Davies G.J., Overkleeft H.S. (2023) 4‐O‐Substituted Glucuronic Cyclophellitols are Selective Mechanism‐Based Heparanase Inhibitors. ChemMedChem, 8, 14, e202200580
26. Doherty G.G., Ler G.J.M, Wimmer N., Bernhardt P.V., Ashmus R.A., Vocadlo D.J., Armstrong Z., Davies G.J., Maccarana M., Li J.-P., Kayal Y., Ferro V. (2023) Synthesis of Uronic Acid 1-Azasugars as Putative Inhibitors of α-Iduronidase, β-Glucuronidase and Heparanase. ChemBioChem, 24, e202200619
2022
25. Armstrong Z., Meek R.W., Wu L., Blaza J.N., Davies G.J. (2022) Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis. Structure, 30, 1-9
24. de Boer C., Armstrong Z.†, Lit V.A.J, Barash U., Ruijgrok G., Boyango I., Weitzenberg M. M. , Schröder S. P., Sarris A.J.C., Meeuwenoord N.J., Bule P., Kayal Y., Ilan N., Codée J.D.C., Vlodavsky I., Overkleeft H.S., Davies G.J., Wu L. (2022) Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proceedings of the National Academy of Sciences, 119, 31, e2203167119
23. Liu F., Chen H.-M., Armstrong Z., Withers S.G. (2022) Azido Groups Hamper Glycan Acceptance by Carbohydrate Processing Enzymes. ACS Central Science, 8, 5, 656–662
22. Scott H., Davies G. J., Armstrong Z. (2022) The structure of Phocaeicola vulgatus sialic acid acetylesterase. Acta Crystallographica Section D, 78, 647–657
21. McGregor N., Kuo C-L., Beenakker T., Wong C-S., Offen W., Armstrong Z., Florea B., Codée J., Overkleeft H. S., Aerts J. M. F. G., Davies G. J. (2022) Synthesis of broad-specificity activity-based probes for exo-β-mannosidases. Organic & Biomolecular Chemistry, 20, 877-886
2021
20. Chen Y., Armstrong Z.†, Artola M., de Boer C., Florea,B. I. van der Marel,G.A., Codée, J. D. C., Aerts, J. M. F. G., Davies G., Overkleeft H. (2021) Activity-based protein profiling of retaining α-amylases in complex biological samples. Journal of the American Chemical Society, 143 (5), 2423-2432
2020
19. Fonseca M., Armstrong Z., Withers S.G., Briers Y. (2020) High-throughput generation of product profiles for arabinoxylan-active enzymes from metagenomes. Applied and Environmental Microbiology, 86 (23)
18. Nieto-Dominguez M., Fernandez de Toro B., de Eugenio L., Santana A., Bejarano-Muñoz L., Armstrong Z., Asensio J., Prieto A., Withers S.G., Cañada F. (2020) Active site mutation of fungal β-xylosidase from the GH3 family reveals outstanding acceptor tolerance: From thio- to multi-glycoligases. Nature Communications, 11:4864
17. Armstrong Z. †, Kuo C-L., Lahav D., Liu B., Johnson R., Beenakker T. J. M., de Boer C., Wong C-S., van Rijssel E. R., Debets M. F., Florea B., Boot R. G., Ovaa H., van der Stelt M., Codée J., Aerts J. M. F. G., Wu L., Overkleeft H., Davies G. (2020) Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. Journal of the American Chemical Society, 142(30) 13021–13029
16. Morgan-Lang C., McLaughlin R., Zhang G., Chan K., Armstrong Z., Konwar K., and Hallam S. J. (2020) TreeSAPP: Phylogenetic Tree-based Sensitive and Accurate Protein Profiling. Bioinformatics, 36 (18), 4706-4713
15. Armstrong Z, Davies G. (2020) Structure and function of Bs164 β-mannosidase from Bacteroides salyersiae the founding member of glycoside hydrolase family GH164. Journal of Biological Chemistry, 295(13) 4316–4326 *Highlighed in a virtual issue on the microbiome: www.jbc.org/site/vi/microbiome/
2019
14. Wu L., Armstrong Z., Schröder S. P., de Boer C., Artola M., Aerts J. M. F. G., Overkleeft H. S., Davies G. (2019) An overview of activity-based probes for glycosidases. Current Opinion in Chemical Biology, 53 25-36
13. Armstrong Z., Liu F., Kheirandish S., Chen H-M., Mewis K., Duo T., Morgan-Lang C., Hallam S. J., Withers S. G., (2019) High-Throughput Recovery and Characterization of Metagenome-Derived Glycoside Hydrolase-Containing Clones as a Resource for Biocatalyst Development. mSystems, 4(4) e00082-19
12. Macdonald S., Armstrong Z., Morgan-Lang C., Osowiecka M., Robinson K., Hallam S.J., Withers S.G., (2019) Development and Application of a High-Throughput Functional Metagenomic Screen for Glycoside Phosphorylases. Cell Chemical Biology, 26(7,) 1001-1012
11. Armstrong Z., Liu F., Chen H.M, Hallam S.J., Withers S.G., (2019) Systematic Screening of Synthetic Gene-Encoded Enzymes for Synthesis of Modified Glycosides. ACS Catalysis 9 (4), 3219-3227
2018
10. Armstrong Z. †, Mewis K., Liu F., Scofield M., Durno E., Chen H.M., Mehr K., Withers S.G., Hallam S.J., (2018) Metagenomics Reveals Functional Specialization and Novel Polysaccharide Utilization Loci in the Castor canadensis Fecal Microbiome. The ISME Journal, 12 (11), 2757
9. The CAZypedia Consortium (2018) Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes. Glycobiology, 28 (1) 3-8
2017
8. Armstrong Z., Rahfeld P., Withers S.G. (2017) Discovery of New Glycosidases from Metagenomic Libraries. Methods in Enzymology, 597, 3-23
2016
7. Nieto-Domínguez M., Prieto A., de Toro B.F., Barriuso J., Armstrong Z., Withers S.G., Eugenio L.I., Martínez M.J. (2016) Enzymatic fine-tuning for 2-(6-hydroxynaphthyl) β-D-xylopyranoside synthesis catalyzed by the recombinant β-xylosidase BxTW1 from Talaromyces amestolkiae. Microbial Cell Factories, 15 (1), 171
6. Chen H.M., Armstrong Z., Hallam S.J., Withers S.G. (2016) Synthesis and evaluation of a series of 6-chloro-4-methylumbelliferyl glycosides as fluorogenic reagents for screening metagenomic libraries for glycosidase activity. Carbohydrate Research, 421, 33-39
2010-2015
5. Armstrong Z., Mewis K., Strachan C., Hallam S.J. (2015) Biocatalysts for biomass deconstruction from environmental genomics. Current Opinion in Chemical Biology, 29, 18-25
4. Armstrong Z., Withers S. G. (2013) Synthesis of glycans and glycopolymers through engineered enzymes. Biopolymers, 99 (10), 666-674
3. Mewis K., Armstrong Z., Song Y.C., Baldwin S.A., Withers S.G., Hallam S.J. (2013) Biomining active cellulases from a mining bioremediation system. Journal of Biotechnology, 167 (4), 462-471
2. Singh, R., Grigg, J.C., Armstrong, Z., Murphy, M.E.P., Eltis, L.D. (2012) Distal Heme Pocket Residues of B-type Dye-decolorizing Peroxidase: Arginine but not Aspartate is Essential for Peroxidase Activity. Journal of Biological Chemistry, 287 (13): 10623-10630
1. Armstrong Z., Reitinger S., Kantner T., Withers S. G. (2010) Enzymatic thioxyloside synthesis: characterization of thioglycoligase variants identified from a site-saturation mutagenesis library of Bacillus circulans xylanase. ChemBioChem, 2010 Mar 1;11(4):533-8.